TA503316 LGR5 / GPR49 antibody

LGR5 mouse monoclonal antibody, clone OTI2A2 (formerly 2A2)

See related secondary antibodies

Search for all "LGR5 / GPR49"

0.1 ml / €379.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.


Quick Overview

Mouse anti Human, Mouse LGR5 / GPR49 OTI2A2


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Product Description for LGR5 / GPR49

Mouse anti Human, Mouse LGR5 / GPR49 OTI2A2.
Presentation: Purified
Product is tested for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for LGR5 / GPR49

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR67, HG38, Leucine-rich repeat-containing G-protein coupled receptor 5
Presentation Purified
Reactivity Hu, Ms
Applications F, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone OTI2A2
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
Human recombinant protein fragment corresponding to amino acids 250-550 of human LGR5 (NP_003658) produced in HEK293T Cell.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application WB 1:2000
IHC 1:150
IF 1:100
FLOW 1:100
IP 2ug/500ul
Product Citations
Originator or purchased from resellers:
  1. Pastò A, Marchesi M, Diamantini A, Frasson C, Curtarello M, Lago C, et al. PKH26 staining defines distinct subsets of normal human colon epithelial cells at different maturation stages. PLoS One. 2012;7(8):e43379. doi: 10.1371/journal.pone.0043379. Epub 2012 Aug 22. PubMed PMID: 22927961. (Free PMC Article available, 5 images available)
  2. Wu C, Xie Y, Gao F, Wang Y, Guo Y, Tian H, et al. Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. Gene. 2013 Aug 1;525(1):18-25. doi: 10.1016/j.gene.2013.04.067. Epub 2013 May 9. PubMed PMID: 23664892.
  3. Jiang N, Zhou J, Chen M, Schiff MD, Lee CH, Kong K, et al. Postnatal epithelium and mesenchyme stem/progenitor cells in bioengineered amelogenesis and dentinogenesis. Biomaterials. 2014 Feb;35(7):2172-80. doi: 10.1016/j.biomaterials.2013.11.061. Epub 2013 Dec 15. PubMed PMID: 24345734. (Free PMC Article available)
  4. Wang J, Guo X, Lui M, Chu PJ, Yoo J, Chang M, et al. Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro. PLoS One. 2014 Jan 17;9(1):e85112. doi: 10.1371/journal.pone.0085112. eCollection 2014. PubMed PMID: 24465489. (Free PMC Article available, 5 images available)
  5. Hsu HC, Liu YS, Tseng KC, Tan BC, Chen SJ, Chen HC. LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/β-catenin signaling pathway in colorectal cancer cells. Cell Signal. 2014 Nov;26(11):2333-42. doi: 10.1016/j.cellsig.2014.07.004. Epub 2014 Jul 12. PubMed PMID: 25025569.
  6. Hsu HC, Liu YS, Tseng KC, Yang TS, Yeh CY, You JF, et al. CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. J Cancer Res Clin Oncol. 2015 Jan;141(1):11-21. doi: 10.1007/s00432-014-1782-4. Epub 2014 Jul 25. PubMed PMID: 25060070.
  7. Shaikh LH, Zhou J, Teo AE, Garg S, Neogi SG, Figg N, et al. LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. J Clin Endocrinol Metab. 2015 Jun;100(6):E836-44. doi: 10.1210/jc.2015-1734. Epub 2015 Apr 27. PubMed PMID: 25915569. (Free PMC Article available, 4 images available)
Purified from mouse ascites fluids by affinity chromatography
Buffer System:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Accessory Products

Proteins and/or Positive Controls

Proteins for LGR5 / GPR49 (2 products)

Catalog No. Species Pres. Purity   Source  

LGR5 / GPR49 (C-term Fc tag)

LGR5 / GPR49 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

LGR5 / GPR49

LGR5 / GPR49 Human
  Abnova Taiwan Corp.

Positive controls for LGR5 / GPR49 (1 products)

Catalog No. Species Pres. Purity   Source  

GPR49 Lysate

Western Blot: GPR49 (LGR5) Lysate [NBL1-12509] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for LGR5
  Novus Biologicals Inc.
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