WDR48 / p80 antibody
Principal name
WDR48 / p80 antibody
Alternative names for WDR48 / p80 antibody
KIAA1449, UAF1, WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein
Available reactivities
Available hosts
Available applications
Paraffin Sections (P), Western blot / Immunoblot (WB)
Background of WDR48 / p80 antibody
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP54546PU-N | WDR48 / p80 (C-term) antibody |
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 |
Rabbit | Ig | Aff - Purified | Hu | P, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
 +1 additional image |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP305497 | WDR48 / p80 |
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| Recombinant protein of human WD repeat domain 48 (WDR48) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR209851L2V | Lenti ORF particles, Wdr48 (GFP-tagged) - Mouse WD repeat domain 48 (cDNA clone MGC:61205 IMAGE:5698339), 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€1,240.00
|
|
| OriGene Technologies, Inc. | ||
| MR209959L2V | Lenti ORF particles, Wdr48 (GFP-tagged) - Mouse WD repeat domain 48 (Wdr48), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,430.00
|
|
| OriGene Technologies, Inc. | ||
| MR209851L1V | Lenti ORF particles, Wdr48 (Myc-DDK-tagged) - Mouse WD repeat domain 48 (cDNA clone MGC:61205 IMAGE:5698339), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,110.00
|
|
| OriGene Technologies, Inc. | ||
| MR209959L1V | Lenti ORF particles, Wdr48 (Myc-DDK-tagged) - Mouse WD repeat domain 48 (Wdr48), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,280.00
|
|
| OriGene Technologies, Inc. | ||
