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DOK4 antibody

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Principal name

DOK4 antibody

Alternative names for DOK4 antibody

Docking protein 4, IRS5, IRS-5, Insulin receptor substrate 5

SwissProt ID

Q8TEW6 (Human), Q99KE3 (Mouse)

Gene ID

55715 (DOK4), 114255 (Dok4)

Ncbi ID

9606, NP_060580.2, NM_018110, NP_060580, NP_444476.1, NM_053246

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of DOK4 antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

General readings

Hooker,E, et al. (2012) Biochem. Biophys. Res. Commun. 427 (1), 67-72
Gerard,A., et al. (2009) J. Immunol. 182 (12), 7681-7689

PAB3408 - DOK4
Formalin-fixed and paraffin-embedded human cancer tissue reacted with DOK4 polyclonal antibody ( Cat # PAB3408 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
AP14445PU-N - DOK4
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
AP14445PU-N - DOK4
Western blot analysis of DOK4 (C-term) (arrow) using DOK4 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DOK4 gene (Lane 2)
C11398-1 - DOK4
Western blot analysis of extracts from 293/mouse lung cells, using DOK4 Antibody. The lane on the right is treated with the synthesized peptide.
ARP60242_P050 - DOK4
Human Heart; WB Suggested Anti-DOK4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human heart; DOK4 antibody - C-terminal region (ARP60242_P050) in Human Heart cells using Western Blot
ARP60243_P050 - DOK4
Human 721_B; WB Suggested Anti-DOK4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: 721_B cell lysate. There is BioGPS gene expression data showing that DOK4 is expressed in 721_B.; DOK4 antibody - N-terminal region (ARP60243_P050) in Human 721_B cells using Western Blot
AR51415PU-N - DOK4
TP760935 - DOK4
TA315601 - DOK4
Western blot analysis of extracts from 293 cells and mouse lung cells, using DOK4 antibody.The lane on the right is treated with the synthesized peptide.
TA332374 - DOK4
Western blot analysis of extracts of MCF7 cells, using DOK4 antibody.
TA332374 - DOK4
Immunohistochemistry of paraffin-embedded Prostate cancer using DOK4 Antibody.
TA332374 - DOK4
Immunohistochemistry of paraffin-embedded human stomach cancer using DOK4 antibody at dilution of 1:200 (200x lens).
TA332374 - DOK4
Immunohistochemistry of paraffin-embedded mouse kidney using DOK4 antibody at dilution of 1:200 (200x lens).
TA332374 - DOK4
Immunofluorescence analysis of HeLa cell using DOK4 antibody. Blue: DAPI for nuclear staining.
TA342886 - DOK4
WB Suggested Anti-DOK4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human heart
TA342887 - DOK4
WB Suggested Anti-DOK4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysate There is BioGPS gene expression data showing that DOK4 is expressed in 721_B
TA349597 - DOK4
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (DOK4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
TA349597 - DOK4
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (DOK4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DOK4 antibody
  Rabbit Polyclonal Anti-DOK4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (DOK4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

DOK4 (C-term) antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+1 additional image

2 Item(s)

per page

Active Filters

  1. Remove This Filter Clonality: Polyclonal
  2. Remove This Filter Applications: Paraffin Sections (P)
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Available Filters

Product Type
  1. Primary Antibody (2)
Target
  1. DOK4 (2)
Property
  1. C-term (1)
Reactivity
  1. Human (Hu) (2)
  2. Mouse (Ms) (1)
Presentation
  1. Purified (2)
Host
  1. Rabbit (2)
Images
  1. 1 image (2)
Images: Applications
  1. IHC (1)
  2. Paraffin Sections (P) (1)
  3. Western blot / Immunoblot (WB) (1)
Manufacturer
  1. OriGene Technologies (2)
Service
  • OriGene Technologies GmbH
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