TA319614 APBA2 (Center) antibody

Rabbit Polyclonal APBA2 Antibody

See related secondary antibodies

Search for all "APBA2"

0.1 mg / €415.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human APBA2

TA319614

More Views

  • TA319614
  • TA319614

Product Description for APBA2

Rabbit anti Human APBA2.
Properties: (Center)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for APBA2

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, MINT2, Mint-2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, X11L
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q99767
Immunogen:
18 amino acid peptide near the center of human APBA2
GeneID:
321
Property Center
Application ELISA.
Western blot: 1-2 µg/ml.
Positive control: Human Brain Tissue Lysate.
Background APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
General Readings
  1. Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM. Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. Mamm Genome. 1998 Jun;9(6):473-5. PubMed PMID: 9585438.
  2. McLoughlin DM, Irving NG, Brownlees J, Brion JP, Leroy K, Miller CC. Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. Eur J Neurosci. 1999 Jun;11(6):1988-94. PubMed PMID: 10336668.
  3. Lee JH, Lau KF, Perkinton MS, Standen CL, Rogelj B, Falinska A, et al. The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. J Biol Chem. 2004 Nov 19;279(47):49099-104. Epub 2004 Sep 3. PubMed PMID: 15347685.
  4. Lee HW, Park JW, Sandagsuren EU, Kim KB, Yoo JJ, Chung SH. Overexpression of APP stimulates basal and constitutive exocytosis in PC12 cells. Neurosci Lett. 2008 May 9;436(2):245-9. doi: 10.1016/j.neulet.2008.03.038. Epub 2008 Mar 19. PubMed PMID: 18395981.
Storage Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects APBA2 at Center.

Accessory Products

  • LinkedIn