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SM3083F CD38 antibody

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100 Tests / €260.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Highly validated antibody!

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Mouse anti Human CD38 HIT2

SM3083F

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  • SM3083F
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  • SM3083F

Product Description for CD38

Mouse anti Human CD38 HIT2.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD38

Product Category Primary Antibodies
Target Category
Quantity 100 Tests
Synonyms ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, cADPr hydrolase 1
Presentation FITC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone HIT2
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P28907
Immunogen:
Human thymocytes in foetus
GeneID:
952
Isotype control SM10F (for use in human samples)
Application Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension.
Background CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
General Readings
  1. Cakir-Kiefer C, Muller-Steffner H, Oppenheimer N, Schuber F. Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling. Biochem J. 2001 Sep 1;358(Pt 2):399-406. PubMed PMID: 11513738. (Free PMC Article available)
  2. Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, et al. CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism. Int Immunol. 2006 Jul;18(7):1029-42. Epub 2006 May 23. PubMed PMID: 16720618.
  3. Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, et al. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. J Immunol. 2007 Dec 1;179(11):7827-39. PubMed PMID: 18025229.
  4. Leukocyte Typing III., McMichael A.J. et al (Eds.), Oxford University Press (1987).
  5. Rozková D, Novotná L, Pytlík R, Hochová I, Kozák T, Bartůnková J, et al. Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation. Int J Cancer. 2010 Mar 1;126(5):1132-43. doi: 10.1002/ijc.24832. PubMed PMID: 19685493.
  6. Kolar GR, Mehta D, Pelayo R, Capra JD. A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood. 2007 Mar 15;109(6):2545-52. Epub 2006 Nov 28. PubMed PMID: 17132718. (Free PMC Article available, 5 images available)
  7. Všianská P, Říhová L, Varmužová T, Suská R, Kryukov F, Mikulášová A, et al. Analysis of B-cell subpopulations in monoclonal gammopathies. Clin Lymphoma Myeloma Leuk. 2015 Apr;15(4):e61-71. doi: 10.1016/j.clml.2014.12.003. Epub 2014 Dec 12. PubMed PMID: 25578543.
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
FITC
Buffer System:
Phosphate buffered saline (PBS) solution containing 15mM sodium azide
State:
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody reacts with CD38 (T10), a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells.
Gene ID 952
FocusOn and Reviews
FocusOns:

Accessory Products

Proteins and/or Positive Controls

Proteins for CD38 (6 products)

Catalog No. Species Pres. Purity   Source  

CD38 (43-300, His-tag)
CD38 Human Purified > 90 % by SDS - PAGE
0.25 mg / €1,070.00
  OriGene Technologies GmbH

CD38 (43-300, His-tag)
CD38 Human Purified > 90 % by SDS - PAGE
50 µg / €320.00
  OriGene Technologies GmbH

CD38
CD38 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD38
CD38 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD38
CD38 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD38
CD38 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for CD38 (2 products)

Catalog No. Species Pres. Purity   Source  

CD38 Lysate
Western Blot: CD38 Lysate [NBL1-08942] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for CD38
  Novus Biologicals Inc.

CD38 overexpression lysate
CD38 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

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Click here to see all secondary antibodies for CD38
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