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AM08047LE-N CD49e / ITGA5 antibody

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0.5 mg / €390.00
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Quick Overview

Rat anti Mouse CD49e / ITGA5 5H10-27

AM08047LE-N

Product Description for CD49e / ITGA5

Rat anti Mouse CD49e / ITGA5 5H10-27.
Presentation: Low Endotoxin
Product is tested for Frozen Sections, Functional assay, Flow Cytometry.

Properties for CD49e / ITGA5

Product Category Primary Antibodies
Target Category
Quantity 0.5 mg
Synonyms CD49 antigen-like family member E, FNRA, Fibronectin receptor subunit alpha, Integrin alpha-5, Integrin alpha-F, VLA-5, VLA5
Presentation Low Endotoxin
Reactivity Ms
Applications C, F, FN
Clonality Monoclonal
Clone 5H10-27
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P11688
Immunogen:
C57BL/6 x A/J F1 mouse mast cell line MC/9. (Ref.1)
Isotype control SM26LE
Application Flow Cytometry. (Ref.1)
Immunohistochemistry on Frozen Sections: (Ref.7)
Functional Assays:
In vitro blocking of adhesion. (Ref.1,2-4,6)
T-cell co-stimulation. (Ref.3)
Background Integrin alpha 5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signalling. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines.
Concentration 0.5 mg/ml
General Readings
  1. Kinashi, T., and T.A. Springer. 1994. Blood Cells 20:25.
  2. Halvorson, M.J., and J.E. Coligan. 1995. J. Immunol. 155:4567.
  3. Rich, S., N. van Nood, and H.-M Lee. 1996. J. Immunol. 157:2916.
  4. Uhlenkott, C.E., J.C. Huijzer, D.J. Cardeiro, C.A. Elstad, and G.G. Meadows. 1996. Clin. Exp. Metastasis 14:125.
  5. Hemler, M.E. 1990. Annu. Rev. Immunol. 8:365.
  6. Schultz, J.F., and D.R. Armant. 1995. J. Biol Chem. 270:11522.
  7. Southern Biotechnology Associates, Inc. Unpublished observations.
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS containing no preservatives.
State:
Liquid purified Ig fraction.
Low Endotoxin
Specificity
Specificity:
This antibody is specific to alpha-5 subunit of the integrin alpha-5 beta-1 Fibronectin Receptor.
It reacts with the alpha-5 chain (VLA-5) of the CD49e/CD29 heterodimeric Fibronectin Receptor. (Ref.1-5)
Soluble 5H10-27 antibody inhibits VLA-5-mediated functions in vitro. (Ref.1,2-4,6) Immobilized 5H10-27 has also been demonstrated to co-stimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3 monoclonal antibody. (Ref.3)
Species:
Mouse.

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