discontinued

TA352095 ENO2 antibody

Mouse Monoclonal anti-NSE Antibody

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Mouse anti Human ENO2 NSE-P2

Product Description for ENO2

Mouse anti Human ENO2 NSE-P2.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for ENO2

Product Category Primary Antibodies
Quantity 200 µl
Presentation Purified
Reactivity Hu
Applications E, P, WB
Clonality Monoclonal
Clone NSE-P2
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Immunogen:
This antibody was raised against a synthetic peptide corresponding to amino acids 271-285. It recognizes the sequence TGDQLGALYQDFVRD.
GeneID:
2026
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application IHC
ELISA
WB
Background Neuron specific enolase is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung cancer.Neuron specific enolase (NSE) converts 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. It is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or as enolase alpha, beta and gamma. The three enolases have different cell type specific expression patterns, so that antibodies to them are useful cell type specific markers. NSE corresponds to ENO2 or enolase gamma and is heavily expressed in neuronal cells. Neurons require a great deal of energy and have high levels of glycolytic enzymes such as NSE. Antibodies to this NSE are useful for identifications of neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury.
Format
Purification:
The antibody was purified by affinity chromatography.
Buffer System:
Phosphate-buffered solution + 0.03% thimerosal.
State:
Purified

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