discontinued

AP05936PU-N GABRA1 (N-term) antibody

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Rabbit anti Mouse, Rat GABRA1

AP05936PU-N

Product Description for GABRA1

Rabbit anti Mouse, Rat GABRA1.
Properties: (N-term)
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for GABRA1

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms GABA A receptor subunit alpha-1, GABRA-1, Gamma-aminobutyric acid receptor subunit alpha-1
Presentation Purified
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P62813
Immunogen:
Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to the N-terminal region of rat GABAA receptor Alpha-1 subunit.
GeneID:
29705
Property N-term
Application Western Blot: 1:1000; detects a band of approximately 51kDa in rat brain membrane fractions.
Background GABA A receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABA A site results in increased intracellular chloride concentration and hyperpolarization of the cell.
GABA A receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.
GABA A receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
General Readings
  1. Burt DR, Kamatchi GL. GABAA receptor subtypes: from pharmacology to molecular biology. FASEB J. 1991 Nov;5(14):2916-23. PubMed PMID: 1661244.
  2. Olsen, R.W. and Tobin, A.J. (1990) Molecular biology of GABAA receptors. FASEB J. 4: 1469-1480.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
10mM Hepes, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin, 50% Glycerol
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody recognises an epitope within the N-terminal region (NT) of the alpha 1 subunit of rat gamma-aminobutyric acid (A) (GABA A) receptor.
Species:
Rat, Mouse.
Gene ID 29705

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