Product Description for Tryptophan 5-hydroxylase 2 (TPH2)
Rabbit anti Bovine, Mouse, Rat, Zebrafish Tryptophan 5-hydroxylase 2 (TPH2).
Properties: pSer19
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Properties: pSer19
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Properties for Tryptophan 5-hydroxylase 2 (TPH2)
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 0.1 ml |
| Synonyms | NTPH, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2 |
| Presentation | Purified |
| Reactivity | Bov, Ms, Rt, Ze |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Polyclonal Antibodies (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Property | pSer19 |
| Application | Western Blot: 1:1000; detects a band of approximately 55kDa on recombinant TPH2 incubated in the presence of CAMKII. |
| Background | Tryptophan Hydroxylase (TPH) is a rate-limiting enzyme which catalyses the 5-hydroxylation of tryptophan, to form the amino acid 5-hydroxytryptophan (5-HTP), in the first stage of the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine/5HT). Mammalian TPH is encoded by two genes: TPH1 expressed in peripheral tissues e.g. skin and gut, and TPH2 primarily expressed in the brain. Studies have demonstrated the regulation/enhancement of TPH activity through phosphorylation by cAMP?dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaMKII), the latter of which phosphorylates a Ser19 site within the regulatory domain of TPH2. |
| Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
| General Readings |
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| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format |
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| Specificity |
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| Gene ID | 121278 |
Accessory Products
Proteins and/or Positive Controls
Proteins for Tryptophan 5-hydroxylase 2 (TPH2) (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP321193 |
Tryptophan 5-hydroxylase 2 (TPH2) |
||||||
|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
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| OriGene Technologies, Inc. | |||||||
Recommended Secondary Antibodies for Tryptophan 5-hydroxylase 2 (TPH2) (9 products)
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| R1458C2 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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Goat | Cy2 | |||||
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| R1458C3 |
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Goat | Cy3 | |||||
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| R1458C5 |
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