Product Description for HNMT / HMT
HNMT / HMT.
Presentation: Purified
Presentation: Purified
Properties for HNMT / HMT
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | Histamine N-methyltransferase |
| Presentation | Purified |
| Molecular weight | kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | Histamine N-methyltransferase (HNMT) is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT inactivates histamine by N-methylation. Histamine is involved in regulation and modulation of immune response through the stimulation of four distinct subtypes of receptors, H1, H2, H3, and H4, present on the target cells. Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. It plays an important role in degrading histamine and in regulating the airway response to histamine. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Garcia-Martin E., et al. (2009) Pharmacogenomics. 10(5):867-83. Palikhe NS., et al. (2008) J Clin Pharm Ther. 33(5):465-72. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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