TANK / ITRAF (Isoform "Short" ) (1-119) - AR09179PU-L

Product Description for TANK / ITRAF

TANK / ITRAF.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.5 mg
Synonyms	I-TRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF2
Presentation	Purified
Molecular weight	13.6 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q92844
Purity	> 90 % by SDS - PAGE
Add. information	The sequence of this isoform differs from the canonical sequence as follows: 111-117 RRQEVSS --> DIASAES 118-425 Missing.
Background	TANK, also known as TRAF (tumor necrosis factor receptor-associated Factor)-interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Gatot JS., et al. (2007) J Biol Chem. 282(43):31131-46.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human TANK protein was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI` Molecular weight: (119 aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) Purity: >90% by SDS - PAGE State: Liquid purified protein Purified