Interleukin-32 / IL32 (Isoform 4 / alpha) (His-tag) - AR09185PU-L

Product Description for Interleukin-32 / IL32

Interleukin-32 / IL32.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.5 mg
Synonyms	IL-32, NK4, Natural killer cells protein 4, TAIF, Tumor necrosis factor alpha-inducing factor
Presentation	Purified
Molecular weight	19.1 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P24001
Purity	> 95 % by SDS - PAGE
Background	Interleukin 32 isoform alpha (isoform 4) belongs to cytokine family. This protein expression is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. It has the ability to induce proinflammatory cytokines such as TNFalpha and IL8 in THP1 cells, and activates typical cytokine signaling pathways involving NFkappaB and p38. IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Kim SH., et al. (2005). Immunity. 22(1):131-42. Kobayashi H., et al. (2009). Int J Radiat Oncol Biol Phys. 74(5):1573-9.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human Interleukin 32, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCF PKVLSDDMKK LKARMHQAIE RFYDKMQNAE SGRGQVMSSL AELEDDFKEG YLETVAAYYE EQHPELTPLL EKERDGLRCR GNRSPVPDVE DPATEEPGES FCDKSYGAPR GDKEELTPQK CSEPQSSK` Molecular weight: (168 aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT 10% glycerol Purity: >95% by SDS - PAGE State: Liquid purified protein Purified