Securin / PTTG1 (1-202, His-tag) - AR09247PU-L

Product Description for Securin / PTTG1

Securin / PTTG1.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.5 mg
Synonyms	EAP1, Esp1-associated protein, PTTG, Pituitary tumor-transforming gene 1 protein, TUTR1, Tumor-transforming protein 1
Presentation	Purified
Molecular weight	24.1 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: O95997
Purity	> 80 % by SDS - PAGE
Background	PTTG1, also known as Securin, is primarily involved in the regulation of sister chromatid separation during cell division. It has two identified roles; the first one is to help the transport of separase (cysteine protease) to the nucleus and the second role is to inhibit the catalytic activity of separase. It is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase.
Concentration	0.5 mg/ml (determined by Bradford assay)
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant PTTG1 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI` Molecular weight: (222 aa)
Format	Buffer System: 20mM Tris-HCl buffer (pH8.0) containing 0.1 M NaCl, 20% glycerol, 1mM EDTA, 0.1mM PMSF Endotoxin level: < 0.5 EU per 1 µg of protein (determined by LAL method ) Purity: >80% by SDS - PAGE State: Liquid purified protein Purified