Product Description for BAG3
BAG3.
Presentation: Purified
Presentation: Purified
Properties for BAG3
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | BAG family molecular chaperone regulator 3, BAG-3, BIS, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1 |
| Presentation | Purified |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | BAG3 was reported initially as a protein-refolding cochaperone of the bcl2 binding protein BAG family and as upregulated in response to persistent stress of cellular calcium balance dysregulation. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Also, it has been shown to diminish stress-induced apoptosis. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Kyratsous CA., et al. (2008) Proc Natl Acad Sci U S A. 105(52):20912-7. Virador VM., et al. (2009) PLos One. 4(4):e5136. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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