Product Description for CD333 / FGFR3
CD333 / FGFR3.
Presentation: Purified
Presentation: Purified
Properties for CD333 / FGFR3
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | FGFR-3, Fibroblast growth factor receptor 3, JTK4 |
| Presentation | Purified |
| Molecular weight | 170 kDa |
| Source | Insect cells |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS-PAGE and visualised by silver stain. |
| Add. information | Centrifuge vials before opening! |
| Background | Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the ß isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis. |
| General Readings |
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| Storage | Store Lyophilized at -20°C to -70°C for greater than six months. Reconstituted sFGFR-3a (IIIc)/Fc should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles! |
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