Product Description for VEGF-A
VEGF-A.
Presentation: Purified
Presentation: Purified
Properties for VEGF-A
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 2 µg |
| Synonyms | VEGF, VEGFA, VPF, Vascular endothelial growth factor A, Vascular permeability factor |
| Presentation | Purified |
| Molecular weight | 48 kDa |
| Source | Insect cells |
| Species (Protein) | Mouse |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % > 95%, by SDS-PAGE and visualised by silver stain. |
| Background | Mouse Vascular Endothelial Growth Factor164 (VEGF164) is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF164 have been identified, VEGFR-1 (FLT-1), and VEGFR-2 (Flk-1). Consistent with the endothelial cell-specific action of VEGF164, expression of both receptor genes has been found predominantly but not exclusively on endothelial cells. Expression of VEGFR-1 was also found on human monocytes, neutrophils (PMNs), bovine brain pericytes and villous and extravillous trophoblasts. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo and is also a chemoattractant for monocytes and endothelial cells. At least three different proteins are generated by differential splicing of the mouse VEGF gene: VEGF120, VEGF164 and VEGF188. The most abundant form is VEGF164. Whereas VEGF120 and VEGF164 are secreted proteins, VEGF188 is strongly cellassociated. In additionn, the isoforms VEGF164 and VEGF188 bind to heparin with high affinity. VEGF is apparently a homodimer, but preparations of VEGF show some heterogenity on SDS gels depending of the secretion of different forms and the varying degrees of glycosylation. All dimeric forms posses similar biological activities. There is evidence that heterodimeric molecules between the different isoforms exists and that different cells and tissues express different VEGF isoforms. A related protein of VEGF is placenta growth factor (PlGF) with about 53% homology and VEGF-B with similar biological activities. |
| General Readings |
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| Storage | Store VEGF164 Lyophilized at -20°C to -70°C. Reconstituted VEGF164 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles! Shelf life: One year from despatch. |
| Source | Insect cells |
| Description |
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| Format |
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