FHIT (1-147, His-tag) - AR09473PU-N

Product Description for FHIT

FHIT.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	AP3A hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Dinucleosidetriphosphatase, Fragile histidine triad protein
Presentation	Purified
Molecular weight	17.9 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P49789
Purity	> 95 % by SDS - PAGE
Background	FHIT (fragile histidine triad) is an enzyme that cleaves adenosine 5' PPP 5' A to yield AMP and ADP. FHIT gene encompasses the common fragile site FRA3B on chromosome 3. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. This protein physically associates with ubiquitin conjugating enzyme 9.
Concentration	1.0 mg/ml (determined by Bradford assay)
General Readings	Kmiec Z., et al. (2009) J Physiol Pharmacol. 60(4):63-70. Ahmad F., et al. (2010) J Cancer Res Clin Oncol. 136(3):333-50.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human FHIT, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQLEH HHHHH` Molecular weight: (155 aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol Purity: >95% by SDS - PAGE State: Liquid purified protein Purified