4-1BBL / TNFSF9 (71-254, His-tag) - AR09189PU-N

Product Description for 4-1BBL / TNFSF9

4-1BBL / TNFSF9.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	4-1BB ligand, CD137L, Tumor necrosis factor ligand superfamily member 9
Presentation	Purified
Molecular weight	23.8 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P41273
Purity	> 95 % by SDS - PAGE
Background	4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Lee SW., et al. (2008). Nat Immunol. 9(8):917-26. Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE` Molecular weight: (222aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 20% glycerol Purity: >95% by SDS - PAGE State: Liquid purified IgG Purified