Product Description for LRPAP1 / A2MRAP
LRPAP1 / A2MRAP.
Presentation: Purified
Presentation: Purified
Properties for LRPAP1 / A2MRAP
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, Low density lipoprotein receptor-related protein-associated protein 1, RAP |
| Presentation | Purified |
| Molecular weight | 40 kDa |
| Source | E. coli |
| Species (Protein) | Rat |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 95 % determined by SDS gelelectrophoresis |
| Add. information | Ligand binding to RAP is Ca2+ dependent and e.g. lipid receptors can be released from RAP by a buffer containing 10 mM EDTA (cf. Bajari et al. 2005, see ref. below). Furthermore, buffers containing phosphate should be avoided (it would form precipitates with Ca2+). |
| Application | Protein standard in 1D and 2D SDS gelelectrophoresis. Immunoblotting. Receptor-binding studies. |
| Background | Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. |
| Concentration | 1,0 mg/ml |
| General Readings |
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| Storage | Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody undiluted at -20°C for one month or (in aliquots) at -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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