Product Description for MAT1A
MAT1A.
Presentation: Purified
Presentation: Purified
Properties for MAT1A
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | AMS1, AdoMet synthetase 1, MAT 1, MAT-I/III, MATA1, Methionine adenosyltransferase 1, Methionine adenosyltransferase I/III, S-adenosylmethionine synthetase isoform type-1 |
| Presentation | Purified |
| Molecular weight | 45.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | MAT1A catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. MAT1A expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT2A present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NFκB and TNFα cause a switch from MAT1A to MAT2A expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Tomasi ML., et al. (2009) Gastroenterology. 136(3):1025-36. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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