Product Description for PGD / PGDH
PGD / PGDH.
Presentation: Purified
Presentation: Purified
Properties for PGD / PGDH
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | 6-phosphogluconate dehydrogenase decarboxylating |
| Presentation | Purified |
| Molecular weight | 55.3 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | PGD (Phosphogluconate dehydrogenas), also known as 6PGD, is a 483 amino acid enzyme that is involved in the pentose phosphate shunt. Pentose is required for nucleic acid biosynthesis and the pentose phosphate cycle is a major source of NADPH. PGD deficiency increases the level of erythrocyte pyruvate kinase (PK) activity and reduces glutathione synthetase (GSH), resulting in hemolysis. Defects in PGD are generally asymptomatic and are inherited in an autosomal dominant fashion. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Le TD., et al. (2010) Proc Natl Acad Sci U S A. 107(7):3198-203. Tagen M., et al. (2009) J Immunol. 183(10):6313-9. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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