MTPN (1-118, His-tag) - AR09558PU-L

Product Description for MTPN

MTPN.
Presentation: Purified

Immunogen	Swiss Prot Num: P58546
Purity	> 90 % by SDS - PAGE
Background	MTPN (myotrophin), an ankyrin repeat protein, is stimulates protein synthesis and cardiomyocyte growth to initiate cardiac hypertrophy by activating the NF-kappaB signaling cascade. This protein plays a potential role in cerebellar morphogenesis and may function in differentiation of cerebellar neurons, particularly of granule cells. Elevated levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts.
Concentration	1.0 mg/ml (determined by Bradford assay)
General Readings	Sen S., et al. (2008) J Biol Chem. 283(41):27947-56. Sivasubramanian N., et al (2002) J Biol Chem. 277(26):23888-97.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human MTPN, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPDGLTAFEATDN QAIKALLQ` Molecular weight: (138aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol Purity: >90% by SDS - PAGE State: Liquid purified protein Purified