COMMD1 (1-190, His-tag) - AR09567PU-L

Product Description for COMMD1

COMMD1.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.25 mg
Synonyms	C2orf5, COMM domain-containing protein 1, MURR1, Protein Murr1
Presentation	Purified
Molecular weight	23.3 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q8N668
Purity	> 90 % by SDS - PAGE
Background	COMMD1, also known as copper metabolism MURR1 domain-containing protein 1, is a 190 amino acid protein responsible for inhibition of TNF-induced NFκB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. High expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. This protein interacts directly with COMMD6 and ATP7B, and indirectly with IκB-β and COMMD7.
Concentration	0.5 mg/ml (determined by Bradford assay)
General Readings	Van De Sluis B, et al. (2002) Hum Mol Genet. 11(2):165-73. Müller T, et al. (2003) J Hepatol. 38(2):164-8.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human COMMD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN` Molecular weight: (210aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 M NaCl Purity: >90% by SDS - PAGE State: Liquid purified protein Purified