Product Description for Thymidylate synthase (TS)
Thymidylate synthase (TS).
Presentation: Purified
Presentation: Purified
Properties for Thymidylate synthase (TS)
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | OK/SW-cl.29, TSase, TYMS |
| Presentation | Purified |
| Molecular weight | 37.8 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 95 % SDS - PAGE |
| Background | Thymidylate synthase is an intracellular enzyme critical for de novo synthesis of DNA. This function maintains the dTMP(thymidine-5-prime monophosphate) pool critical for DNA replication and repair. In cancer, expression of this protein is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of thymidylate synthase activity. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Chiu TH., et al. (2009) Anticancer Res. 29(11):4503-11. Pena MM., et al. (2009) J Biol Chem. 284(46):31597-607. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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