Thiopurine methyltransferase (TPMT) (1-245) - AR09087PU-N

Product Description for Thiopurine methyltransferase (TPMT)

Thiopurine methyltransferase (TPMT).
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	Thiopurine S-methyltransferase
Presentation	Purified
Molecular weight	28 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P51580
Purity	≥ 95 pure by SDS-PAGE
Background	TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
Concentration	1.0 mg/ml
General Readings	Odani S, et al.(2001) J Biochem. 129(2):213-9.
Storage	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant Human TPMT was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK` Molecular weight: (245 aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl, 8.0, 0.2 mM PMSF, 2 mM EDTA Purity: ≥95 pure by SDS-PAGE State: Liquid purified protein Purified