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BM116S Proteoglycan 2 antibody

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0.1 mg / €440.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Quick Overview

Mouse anti Human Proteoglycan 2 BMK13

BM116S

Product Description for Proteoglycan 2

Mouse anti Human Proteoglycan 2 BMK13.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot, Paraffin Sections.

Properties for Proteoglycan 2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms BMPG, Bone marrow proteoglycan, EMBP, Eosinophil granule major basic protein, PRG2, Pregnancy-associated major basic protein
Presentation Purified
Reactivity Hu
Applications C, E, P, WB
Clonality Monoclonal
Clone BMK13
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P13727
GeneID:
5553
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application IHC with fresh frozen tissue (fix in methanol:acetone)
IHC with formalin fixed paraffin-embedded tissue (treat with 0.1% trypsin before blocking)
Western blot
ELISA
Background PRG2 is a cytotoxin and helminthotoxin. It also induces noncytolytic histamine release from human basophils and is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
Concentration 0.1 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Hyo S, Kawata R, Kadoyama K, Eguchi N, Kubota T, Takenaka H, et al. Expression of prostaglandin D2 synthase in activated eosinophils in nasal polyps. Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):693-700. PubMed PMID: 17638783.
General Readings
  1. Bernardes JF, Shan J, Tewfik M, Hamid Q, Frenkiel S, Eidelman DH. Protein nitration in chronic sinusitis and nasal polyposis: role of eosinophils. Otolaryngol Head Neck Surg. 2004 Nov;131(5):696-703. PubMed PMID: 15523450.
  2. Ying, S., et al., (2002), Methods for identifying human eosinophils in blood and tissue, ACI International, 14:64-71.
Storage Store the antibody undiluted at 2 - 8°C for one month or at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A chromatography
Buffer System:
PBS with 0.09% sodium azide as preservative and 0.1% BSA as stabilizer.
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
Specific for eosinophil major basic protein irrespective of the stages of eosinophil activation and can be regarded as an eosinophil marker.
The antibody will recognize the 23.8 kDa secreted pro-form of MBP (Pregnancy associated MBP) and the 13.8 kDa mature form found in the matrix of the eosinophil large specific granule.
Species:
Human. Does not cross-react with horse, mouse or rat MBP.
Gene ID 5553

Accessory Products

Proteins and/or Positive Controls

Proteins for Proteoglycan 2 (3 products)

Catalog No. Species Pres. Purity   Source  

Proteoglycan 2
Proteoglycan 2 Human
  Abnova Taiwan Corp.

Proteoglycan 2
Proteoglycan 2 Human in vitro transl.
  Abnova Taiwan Corp.

Proteoglycan 2
Proteoglycan 2 Human in vitro transl.
  Abnova Taiwan Corp.

Positive controls for Proteoglycan 2 (3 products)

Catalog No. Species Pres. Purity   Source  

PRG2 293T Cell Transient Overexpression Lysate(Denatured)
PRG2 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

PRG2 Lysate
Western Blot: PRG2 Lysate [NBL1-14752] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for PRG2
  Novus Biologicals Inc.

PRG2 overexpression lysate
PRG2 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

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