Product Description for Apolipoprotein(a) / LP(a)
Sheep anti Human Apolipoprotein(a) / LP(a).
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.
Properties for Apolipoprotein(a) / LP(a)
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 1 mg |
| Synonyms | Apo(a), LPA |
| Presentation | Aff - Purified |
| Reactivity | Hu |
| Applications | E, WB |
| Clonality | Polyclonal |
| Host | Sheep |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Polyclonal Antibodies (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | Suitable for use in ELISA (1/7,500-1/60,000), Western blot (1/200-1/80,000) and conjugation purposes. |
| Background | Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis. |
| Concentration | 1 mg/ml (OD280nm, E0.1% = 1.35) |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format |
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| Specificity |
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| Gene ID | 4018 |
Accessory Products
Proteins and/or Positive Controls
Proteins for Apolipoprotein(a) / LP(a) (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| BA399 |
Apolipoprotein(a) / LP(a) |
||||||
|
Human | Purified |
Ultracentrifugation and Affinity Chromatography on Lysine-Sepharose. One band on unreduced polyacrylmide/SDS gels. |
Plasma | |||
| OriGene Technologies GmbH | |||||||
| P4941 |
Apolipoprotein(a) / LP(a) |
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|
|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
Recommended Secondary Antibodies for Apolipoprotein(a) / LP(a) (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1433R |
Sheep IgG (H+L chain), adsorbed F(ab')2 Fragment antibody |
||||||
|
|
Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1456AP |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | AP | |||||
| OriGene Technologies GmbH | |||||||
| R1456B |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | |||||
| OriGene Technologies GmbH | |||||||
| R1456F |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | |||||
| OriGene Technologies GmbH | |||||||
| R1456HRP |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | HRP | |||||
| OriGene Technologies GmbH | |||||||
| R1456T |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | TRITC | |||||
| OriGene Technologies GmbH | |||||||
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