Calcipressin-1 (Isoform B) (1-117) - AR09020PU-N

Product Description for Calcipressin-1

Calcipressin-1.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	ADAPT78, CSP1, DSC1, DSCR1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, RCAN1, Regulator of calcineurin 1
Presentation	Purified
Molecular weight	13 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P53805
Purity	> 90 % >/= 90% by SDS PAGE
Add. information	NCBI Accession: NP_981962
Background	The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a.
Concentration	1.0 mg/ml
General Readings	Genesca L., et al. (2003) J Biol Chem. Sep 1;374. Hesser BA., et al. (2004) Blood Jul 1;104(1):149-58. Harris CD., et al. (2007) FEBS J. Apr;274(7):1715-24.
Storage	Store (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Source	E. coli
Description	Description: Recombinant human DSCR1 was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS` Molecular weight: 13 kDa (117 aa)
Format	Buffer System: 20 mM Tris 7.5, 0.1 M NaCl, 1 mM DTT Purity: >90% >/= 90% by SDS PAGE State: Liquid purified protein Purified