Product Description for SIRT3
SIRT3.
Presentation: Purified
Presentation: Purified
Properties for SIRT3
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | NAD-dependent deacetylase sirtuin-3 mitochondrial, SIR2-like protein 3, SIR2L3, SIRT-3, hSIRT3, sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae), sirtuin 3, sirtuin type 3, sirtuin-3 |
| Presentation | Purified |
| Molecular weight | 33.5 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin family of proteins. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance and metabolic regulation. SIRT3 exhibits NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 results in increased levels of the mitochondrial uncoupling protein 1. SIRT3 protein levels are also elevated in certain breast cancers. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Schewr B., et al. (2002) J Cell Biol. 158(4):647-57. Kim H S., et al. (2010) Cancer Cell. 17(1):41-52. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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