CBFB (1-182, His-tag) - AR09605PU-N

Product Description for CBFB

CBFB.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	50 µg
Synonyms	CBF beta, CBF-beta, Core-binding factor beta, PEA2-beta, PEBP2-beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
Presentation	Purified
Molecular weight	23.6 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q13951
Purity	> 85 % by SDS-PAGE
Background	CBFB, also known as PEBP2B, is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). This protein is a non-DNA binding regulatory subunit and it allosterically enhances DNA binding by alpha subunit.
Concentration	0.5 mg/ml (determined by Bradford assay)
General Readings	Speck NA., et al. (2009) Blood. 113(13):3070-9. Ito Y., et al. (2008) Blood. 112(9):3777-87.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human CBFB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP` Molecular weight: (202aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM MES (pH 6.0) containing 0.1 mM PMSF, 10% Glycerol Purity: >85% by SDS-PAGE State: Liquid purified protein Purified