Product Description for CCS / SOD4
CCS / SOD4.
Presentation: Purified
Presentation: Purified
Properties for CCS / SOD4
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | SOD-4, Superoxide Dismutase Copper Chaperone |
| Presentation | Purified |
| Molecular weight | 31.2 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Romerius P., et al. (2010) Clin Cancer Res. 16(15):3843-50. Seetharaman SV., et al. (2010) Biochemistry. 49(27):5714-25. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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