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SP1338PX Calcitonin receptor antibody

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Quick Overview

Rabbit anti Human, Mouse, Rat Calcitonin receptor

SP1338PX

Product Description for Calcitonin receptor

Rabbit anti Human, Mouse, Rat Calcitonin receptor.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for Calcitonin receptor

Product Category Primary Antibodies
Quantity 50 µg
Synonyms CALCR, CT-R, CTR
Presentation Purified
Reactivity Hu, Ms, Rt
Applications C, E, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P32214
Immunogen:
Synthetic peptide derived from C-terminal sequence of Rat Calcitonin Receptor
GeneID:
116506
Add. information Antiserum Preparation: Antisera to calcitonin receptor were raised by repeated immunisations of Rabbits with highly purified antigen.
Application ELISA: 1/10,000. 
Wewstern Blot (Reducing conditions). 
Immunofluorescence.
Immunohistochemistry on Frozen Sections: 1/10-1/50.
Immunohistochemistry on Paraffin Embedded Tissues: 1/10-1/50. The use of 4% paraformaldehyde fixation rather than formalin fixation is recommended. A sensitive detection system is also recommended, e.g. a catalysed signal amplification system. Does not require protein digestion pre-treatment nor antigen retrieval using heat prior to staining of paraffin embedded sections.
Suitable Positive Control: Kidney, cultered osteoclasts.
Background Calcitonin Receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embyro and may be important in foetal morphogenesis.
Concentration 1.0 mg/ml
General Readings
  1. Wookey PJ, Zulli A, Buxton BF, Hare DL. Calcitonin receptor immunoreactivity associated with specific cell types in diseased radial and internal mammary arteries. Histopathology. 2008 Apr;52(5):605-12. doi: 10.1111/j.1365-2559.2008.02979.x. PubMed PMID: 18370957.
  2. Tolcos M, Tikellis C, Rees S, Cooper M, Wookey P. Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat. J Comp Neurol. 2003 Jan 27;456(1):29-38. PubMed PMID: 12508311.
  3. Kovacs CS, Chafe LL, Woodland ML, McDonald KR, Fudge NJ, Wookey PJ. Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E721-32. PubMed PMID: 11832378.
  4. Gnocchi VF, White RB, Ono Y, Ellis JA, Zammit PS. Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells. PLoS One. 2009;4(4):e5205. doi: 10.1371/journal.pone.0005205. Epub 2009 Apr 16. PubMed PMID: 19370151. (Free PMC Article available, 5 images available)
  5. Becskei C, Riediger T, Zünd D, Wookey P, Lutz TA. Immunohistochemical mapping of calcitonin receptors in the adult rat brain. Brain Res. 2004 Dec 31;1030(2):221-33. PubMed PMID: 15571671.
  6. Gooi JH, Pompolo S, Karsdal MA, Kulkarni NH, Kalajzic I, McAhren SH, et al. Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes. Bone. 2010 Jun;46(6):1486-97. doi: 10.1016/j.bone.2010.02.018. Epub 2010 Feb 24. PubMed PMID: 20188226.
  7. Gelsleichter, J.J. (2006) MCAA: Development of laboratory skills in molecular biology to examine patterns of calcitonin and calcitonin receptor gene expression in cartilaginous fishes. Mote technical report 1392.
  8. Wookey PJ, Turner K, Furness JB. Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse. Cell Tissue Res. 2012 Feb;347(2):311-7. doi: 10.1007/s00441-011-1303-6. Epub 2012 Jan 22. PubMed PMID: 22271140.
  9. Mourikis P, Gopalakrishnan S, Sambasivan R, Tajbakhsh S. Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells. Development. 2012 Dec;139(24):4536-48. doi: 10.1242/dev.084756. Epub 2012 Nov 7. PubMed PMID: 23136394.
  10. Park JK, Askin F, Giles JT, Halushka MK, Rosen A, Levine SM. Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis. PLoS One. 2012;7(8):e42659. doi: 10.1371/journal.pone.0042659. Epub 2012 Aug 8. PubMed PMID: 22905158. (Free PMC Article available, 5 images available)
  11. Le Roux I, Konge J, Le Cam L, Flamant P, Tajbakhsh S. Numb is required to prevent p53-dependent senescence following skeletal muscle injury. Nat Commun. 2015 Oct 27;6:8528. doi: 10.1038/ncomms9528. PubMed PMID: 26503169. (Free PMC Article available, 5 images available)
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography on Protein A.
Buffer System:
PBS containing 0.09% Sodium Azide as preservative.
State:
Liquid purified IgG fraction.
Purified
Species Reactivity
Species reactivity (tested):
Rat, Mouse, Human, Fish, Atlantic Stingray.
Specificity
Specificity:
SP1338P reacts with the Calcitonin Receptor.
It recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b Rat isoforms.
Gene ID 116506

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