Product Description for CD340 / ERBB2 / HER2
anti CD340 / ERBB2 / HER2.
Properties: control peptide
Presentation: Purified
Properties: control peptide
Presentation: Purified
Properties for CD340 / ERBB2 / HER2
| Product Category | Control Peptides |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | HER-2, MNL19, NEU, NEU proto-oncogene, NGL, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, c-erbB-2, p185erbB2 |
| Presentation | Purified |
| Clonality | Polyclonal |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Monoclonal Antibodies (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Add. information | Peptide Sequence: Amino - D I D E T E pY H A D G G K V S S - amide |
| Application | For competition experiments start with 200 fold molar excess of the blocking peptide. e.g.: 0.2µg/ml mab and 10µg/ml peptide (MW 2000). |
| Background | ErbB2 is a member of the EGFR/erbB-receptor tyrosine kinase family. ErbB2 is activated upon ligand dependent heterodimerization with EGFR or erbB4. ErbB2 homodimers are not favored due to the lack of an erbB2 specific extracellular ligand. Heterodimerization with EGFR or erbB4 leads to activation of the intrinsic tyrosine kinase activity of EGFR or erbB4 resulting in phosphorylation of multiple tyrosine residues within the erbB2 intracellular domain: Tyr 1023, Tyr 1112, Tyr 1139, Tyr 1196, Tyr 1222, and Tyr 1248. Transphosphorylation via src family kinases leads to phosphorylation of Tyr 877, via PKC of Thr 686, via CamKinase2 of Ser 1113. Phosphorylation of Thr 686 and Ser 1113 interferes with erbB2 endocytosis and degradation. |
| Storage | Lyophilized peptide can be stored below -20°C for 2 years from delivery. Upon reconstitution, aliquote and freeze in liquid nitrogen. Reconstituted peptide can be stored frozen at -80°C up to 1 year. Thaw aliquots at 37°C. Thawed aliquots may be stored at 2-8°C up to 1 week. Avoid repeated freeze-thaw cycles. |
| Format |
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| Specificity |
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| Gene ID | 2064 |
Accessory Products
Recommended Secondary Antibodies for CD340 / ERBB2 / HER2 (0 products)
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