Product Description for Deoxycytidine kinase
Deoxycytidine kinase.
Presentation: Purified
Presentation: Purified
Properties for Deoxycytidine kinase
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | DCK, MGC117410, MGC138632 |
| Presentation | Purified |
| Molecular weight | 34.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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|---|---|
| Purity | > 90 % |
| Background | DCK is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. This protein is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Radu CG., et al. (2010) Proc Natl Acad Sci U S A. 107(12):5551-6. Ribeiro R., et al. (2007) J Pharmacol Exp Ther. 323(3):935-45. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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