PTRH2 / BIT1 (64-179, His-tag) - AR09770PU-N

Product Description for PTRH2 / BIT1

PTRH2 / BIT1.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	CGI-147, PTH2, Peptidyl-tRNA hydrolase 2 mitochondrial
Presentation	Purified
Molecular weight	14.9 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q9Y3E5
Purity	> 95 %
Background	PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1, is a mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondria to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. The natural substrate for PTRH2 may be petidyl-tRNAs which drop off the ribosome during protein synthesis.
Concentration	1.0 mg/ml (determined by Bradford assay)
General Readings	Jan Y., et al. (2004) Cell. 116(5):751-62. De Pereda JM., et al. (2004) J Biol Chem. 279(9):8111-5.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human PTRH2 protein was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MEYKMILVVR NDLKMGKGKV AAQCSHAAVS AYKQIQRRNP EMLKQWEYCG QPKVVVKAPD EETLIALLAH AKMLGLTVSL IQDAGRTQIA PGSQTVLGIG PGPADLIDKV TGHLKLY` Molecular weight: (137aa), confirmed by MALDI-TOF
Format	Buffer System: 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT Purity: >95% State: Liquid purified protein Purified