Product Description for NELF-E
NELF-E.
Presentation: Purified
Presentation: Purified
Properties for NELF-E
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | NELFE, Negative elongation factor E, RD, RDBP |
| Presentation | Purified |
| Molecular weight | 45.4 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 85 % |
| Background | NELF-E (RDBP) is a putative RNA binding protein. This protein is one of the five components of the multisubunit NELF complex that cooperates with DSIF to repress RNA polymerase II elongation. Control of transcription elongation requires a complex interplay between positive transcription elongation factor b and negative transcription elongation factors, DSIF and NELF. DSIF and NELF, act as negative transcription elongation factors by increasing the time the polymerase spends at pause sites. NELF-E has a functional RNA-binding domain, whose mutations impair transcription repression without affecting known protein-protein interactions. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Wada T., et al. (2000) Mol Cell. 5(6):1067-72. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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