Product Description for MTHFS
MTHFS.
Presentation: Purified
Presentation: Purified
Properties for MTHFS
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | 10-methenyl-tetrahydrofolate synthetase, 5, 5-formyltetrahydrofolate cyclo-ligase, Methenyl-THF synthetase |
| Presentation | Purified |
| Molecular weight | 25.4 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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|---|---|
| Purity | > 95 % |
| Background | MTHFS, also known as 5-formyltetrahydrofolate cyclo-ligase, is a cytosolic protein involved in the formate metabolic process. MTHFS, with a magnesium cofactor, catalyzes the ATP-dependent reaction that reduces 5-formyltetrahydrofolate (5-MTHF) to 5,10-methenyltetrahydrofolate(MTHF). MTHF is the substrate used by MTHFR (methylenetetrahydrofolate reductase) to generate 5-MTHF. MTHF is also a coenzyme used in thymidine biosynthesis by thymidylate synthase (FAD). |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Field, M.S., et al. (2006) J. Biol. Chem. 281: 4215-4221. Lim, U., et al. (2007) Blood 109: 3050-3059. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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