discontinued

DDX0120P-50 CD21 (CD21L) antibody

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Mouse anti Human CD21 7D6

DDX0120P-50

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  • DDX0120P-50

Product Description for CD21

Mouse anti Human CD21 7D6.
Properties: (CD21L)
Presentation: Purified
Product is tested for Frozen Sections.

Properties for CD21

Product Category Primary Antibodies
Quantity 50 µg
Synonyms C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor
Presentation Purified
Reactivity Hu
Applications C
Clonality Monoclonal
Clone 7D6
Host Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
P20023
Immunogen:
enriched-human tonsillar FDCs (follicular dendritic cells)
GeneID:
1380
Property CD21L
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application IHC frozen section. 
Usage recommendation:
*This monoclonal antibody may be used between 1-15 μg/ml.
Background An antibody has been generated that specifically recognizes human follicular dendritic cells (FDCs) on the long CR2 / CD21L isoform (CD21L). Follicular dendritic cells represent a cell-type ontogenetically distinct from all other Dendritic Cells (DCs). They are found within B lymphocyte follicles of secondary lymphoid tissue. At the opposite, B lymphocytes selectively express the short CR2 / CD21 lacking exon 10a (CD21S). mAb 7D6 does not recognize CD21 expressed on other cells. (Liu Y.J. et al, 1997; J. Exp. Med.185: 165-170)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Liu YJ, Xu J, de Bouteiller O, Parham CL, Grouard G, Djossou O, et al. Follicular dendritic cells specifically express the long CR2/CD21 isoform. J Exp Med. 1997 Jan 6;185(1):165-70. PubMed PMID: 8996252. (Free PMC Article available, 5 images available)
  2. Lindhout E, van Eijk M, van Pel M, Lindeman J, Dinant HJ, de Groot C. Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells. J Immunol. 1999 May 15;162(10):5949-56. PubMed PMID: 10229832.
  3. Estes JD, Thacker TC, Hampton DL, Kell SA, Keele BF, Palenske EA, et al. Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration. J Immunol. 2004 Nov 15;173(10):6169-78. PubMed PMID: 15528354.
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Format
Purification:
QMA Hyper D ion exchange chromatography
State:
100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
Purified
Specificity
Specificity:
human follicular dendritic cells
Gene ID 1380

Accessory Products

Proteins and/or Positive Controls

Proteins for CD21 (1 products)

Catalog No. Species Pres. Purity   Source  

CD21 (transcript variant 2)

CD21 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €788.00
  OriGene Technologies, Inc.

Positive controls for CD21 (1 products)

Catalog No. Species Pres. Purity   Source  

CR2 overexpression lysate

CR2 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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