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DDX0190B-50 CD208 / LAMP3 antibody

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Mouse anti Human, Sheep CD208 / LAMP3 104G4

DDX0190B-50

Product Description for CD208 / LAMP3

Mouse anti Human, Sheep CD208 / LAMP3 104G4.
Presentation: Biotin
Product is tested for Frozen Sections, Flow Cytometry.

Properties for CD208 / LAMP3

Product Category Primary Antibodies
Quantity 50 µg
Synonyms DC-LAMP, DC-lysosome-associated membrane glycoprotein, DCLAMP, Dendritic Cell Marker, Lysosomal-associated membrane protein 3, Lysosome-associated membrane glycoprotein 3, Protein TSC403, TSC403
Presentation Biotin
Reactivity Hu, Sh
Applications C, F
Clonality Monoclonal
Clone 104G4
Host Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9UQV4
Immunogen:
human DC-LAMP alkaline phosphatase fusion protein
GeneID:
27074
Isotype control SM10B (for use in human samples)
Application Intracyto Flow cytometry, IHC
Background The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
(de Saint-Vis B et al, 1998 ; Immunity ; 9:325-336)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. de Saint-Vis B, Vincent J, Vandenabeele S, Vanbervliet B, Pin JJ, Aït-Yahia S, et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998 Sep;9(3):325-36. PubMed PMID: 9768752.
  2. Bonneau M, Epardaud M, Payot F, Niborski V, Thoulouze MI, Bernex F, et al. Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node. J Leukoc Biol. 2006 Feb;79(2):268-76. Epub 2005 Dec 5. PubMed PMID: 16330534.
  3. Elliott B, Scolyer RA, Suciu S, Lebecque S, Rimoldi D, Gugerli O, et al. Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma. Clin Cancer Res. 2007 Jul 1;13(13):3825-30. PubMed PMID: 17606713.
  4. Mayer WJ et al, 2007
  5. Lebre MC, Jongbloed SL, Tas SW, Smeets TJ, McInnes IB, Tak PP. Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles. Am J Pathol. 2008 Apr;172(4):940-50. doi: 10.2353/ajpath.2008.070703. Epub 2008 Feb 21. PubMed PMID: 18292234. (Free PMC Article available, 6 images available)
  6. Huch JH, Cunningham AL, Arvin AM, Nasr N, Santegoets SJ, Slobedman E, et al. Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. J Virol. 2010 Apr;84(8):4060-72. doi: 10.1128/JVI.01450-09. Epub 2010 Feb 3. PubMed PMID: 20130046. (Free PMC Article available, 8 images available)
  7. Vermi W, Fisogni S, Salogni L, Schärer L, Kutzner H, Sozzani S, et al. Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J Invest Dermatol. 2011 Feb;131(2):426-34. doi: 10.1038/jid.2010.256. Epub 2010 Aug 26. PubMed PMID: 20739948.
  8. van Dongen M et al, 2010
  9. Schwingshackl P, Obermoser G, Nguyen VA, Fritsch P, Sepp N, Romani N. Distribution and maturation of skin dendritic cell subsets in two forms of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Acta Derm Venereol. 2012 May;92(3):269-75. doi: 10.2340/00015555-1220. PubMed PMID: 22678564.
  10. Romani N et al , 2012
  11. Irla N, Navarini AA, Yawalkar N. Alitretinoin abrogates innate inflammation in palmoplantar pustular psoriasis. Br J Dermatol. 2012 Nov;167(5):1170-4. doi: 10.1111/j.1365-2133.2012.11063.x. Epub 2012 Sep 13. PubMed PMID: 22612660.
  12. Takechi H, Oda T, Hotta O, Yamamoto K, Oshima N, Matsunobu T, et al. Clinical and immunological implications of increase in CD208+ dendritic cells in tonsils of patients with immunoglobulin A nephropathy. Nephrol Dial Transplant. 2013 Dec;28(12):3004-13. doi: 10.1093/ndt/gft399. Epub 2013 Sep 29. PubMed PMID: 24081865. (Free PMC Article available, 7 images available)
  13. Debeer S et al, 2013
  14. Pavot V et al, 2014
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Coupled antibodies: glycerol protects from freezing.
Format
Label:
Biotin
State:
100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol
Specificity
Specificity:
human DC-LAMP (epitope in intracytoplasmic domain). 
Species cross-reactivity: sheep.
Gene ID 27074

Accessory Products

Proteins and/or Positive Controls

Proteins for CD208 / LAMP3 (4 products)

Catalog No. Species Pres. Purity   Source  

CD208 / LAMP3 (28-381, His-tag)
CD208 / LAMP3 Human Purified > 90 % by SDS – PAGE Insect cells
0.25 mg / €1,070.00
  OriGene Technologies GmbH

CD208 / LAMP3 (28-381, His-tag)
CD208 / LAMP3 Human Purified > 90 % by SDS – PAGE Insect cells
50 µg / €320.00
  OriGene Technologies GmbH

CD208 / LAMP3
CD208 / LAMP3 Human Human HEK293T cells
  Abnova Taiwan Corp.

CD208 / LAMP3
CD208 / LAMP3 Human
  Abnova Taiwan Corp.

Positive controls for CD208 / LAMP3 (2 products)

Catalog No. Species Pres. Purity   Source  

LAMP3 Lysate
Western Blot: LAMP3 Lysate [NBL1-12432] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for LAMP3
  Novus Biologicals Inc.

LAMP3 overexpression lysate
LAMP3 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

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