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DDX0191P-50 CD208 / LAMP3 antibody

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Rat anti Canine, Feline, Human, Mouse, Sheep CD208 / LAMP3 1010E1.01

DDX0191P-50

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  • DDX0191P-50
  • DDX0191P-50

Product Description for CD208 / LAMP3

Rat anti Canine, Feline, Human, Mouse, Sheep CD208 / LAMP3 1010E1.01.
Presentation: Purified
Product is tested for Frozen Sections, Paraffin Sections.

Properties for CD208 / LAMP3

Product Category Primary Antibodies
Quantity 50 µg
Synonyms DC-LAMP, DC-lysosome-associated membrane glycoprotein, DCLAMP, Dendritic Cell Marker, Lysosomal-associated membrane protein 3, Lysosome-associated membrane glycoprotein 3, Protein TSC403, TSC403
Presentation Purified
Reactivity Can, Fe, Hu, Ms, Sh
Applications C, P
Clonality Monoclonal
Clone 1010E1.01
Host Rat
Isotype IgG2a
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9UQV4
Immunogen:
recombinant murine DC LAMP
GeneID:
27074
Isotype control SM15P, SM15PX
Application IHC paraffin (formol, Bouin) in human
Background The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
(de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. de Saint-Vis B, Vincent J, Vandenabeele S, Vanbervliet B, Pin JJ, Aït-Yahia S, et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998 Sep;9(3):325-36. PubMed PMID: 9768752.
  2. Salaun B, de Saint-Vis B, Clair-Moninot V, Pin JJ, Barthélemy-Dubois C, Kissenpfennig A, et al. Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 2003 Sep;33(9):2619-29. PubMed PMID: 12938238.
  3. Salaun B, de Saint-Vis B, Pacheco N, Pacheco Y, Riesler A, Isaac S, et al. CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 2004 Mar;164(3):861-71. PubMed PMID: 14982840. (Free PMC Article available, 7 images available)
  4. Treilleux I, Blay JY, Bendriss-Vermare N, Ray-Coquard I, Bachelot T, Guastalla JP, et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin Cancer Res. 2004 Nov 15;10(22):7466-74. PubMed PMID: 15569976.
  5. Elliott B, Scolyer RA, Suciu S, Lebecque S, Rimoldi D, Gugerli O, et al. Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma. Clin Cancer Res. 2007 Jul 1;13(13):3825-30. PubMed PMID: 17606713.
  6. Dieu-Nosjean MC, Massacrier C, Homey B, Vanbervliet B, Pin JJ, Vicari A, et al. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med. 2000 Sep 4;192(5):705-18. PubMed PMID: 10974036. (Free PMC Article available, 10 images available)
  7. Bailey CC, Huang IC, Kam C, Farzan M. Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog. 2012 Sep;8(9):e1002909. doi: 10.1371/journal.ppat.1002909. Epub 2012 Sep 6. PubMed PMID: 22969429. (Free PMC Article available, 5 images available)
  8. Romero-Palomo F, Risalde MA, Molina V, Sánchez-Cordón PJ, Pedrera M, Gómez-Villamandos JC. Immunohistochemical detection of dendritic cell markers in cattle. Vet Pathol. 2013 Nov;50(6):1099-108. doi: 10.1177/0300985813482951. Epub 2013 Mar 25. PubMed PMID: 23528943.
  9. Berbic M, Ng CH, Black K, Markham R, Russell P, Basten A, et al. A novel pilot study of endometrial stromal cells and immune cell populations in sentinel uterine-draining lymph nodes during the menstrual cycle and in endometriosis. Reprod Sci. 2013 Nov;20(11):1339-48. doi: 10.1177/1933719113485298. Epub 2013 May 29. PubMed PMID: 23719712.
  10. Martinet L, Filleron T, Le Guellec S, Rochaix P, Garrido I, Girard JP. High endothelial venule blood vessels for tumor-infiltrating lymphocytes are associated with lymphotoxin β-producing dendritic cells in human breast cancer. J Immunol. 2013 Aug 15;191(4):2001-8. doi: 10.4049/jimmunol.1300872. Epub 2013 Jul 3. PubMed PMID: 23825314.
  11. Remark R, Alifano M, Cremer I, Lupo A, Dieu-Nosjean MC, Riquet M, et al. Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin. Clin Cancer Res. 2013 Aug 1;19(15):4079-91. doi: 10.1158/1078-0432.CCR-12-3847. Epub 2013 Jun 19. PubMed PMID: 23785047.
  12. Debeer S, Le Luduec JB, Kaiserlian D, Laurent P, Nicolas JF, Dubois B, et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol. 2013 Jul-Aug;23(4):456-66. doi: 10.1684/ejd.2013.2060. PubMed PMID: 24047577.
  13. Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, et al. Cancer Res 2014;74:705-715. Published OnlineFirst December 23, 2013. doi:10.1158/0008-5472.CAN-13-1342.
  14. Alifano M, Mansuet-Lupo A, Lococo F, Roche N, Bobbio A, Canny E, et al. Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer. PLoS One. 2014 Sep 19;9(9):e106914. doi: 10.1371/journal.pone.0106914. eCollection 2014. PubMed PMID: 25238252. (Free PMC Article available)
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Format
Purification:
QMA Hyper D ion exchange chromatography
Buffer System:
Tris-NaCl pH 8
State:
Purified
Specificity
Specificity:
murine DC-LAMP (epitope in intracytoplasmic domain). 
Species cross-reactivity: human, cat, dog, sheep, mouse.
Gene ID 239739

Accessory Products

Proteins and/or Positive Controls

Proteins for CD208 / LAMP3 (4 products)

Catalog No. Species Pres. Purity   Source  

CD208 / LAMP3 (28-381, His-tag)
CD208 / LAMP3 Human Purified > 90 % by SDS – PAGE Insect cells
0.25 mg / €1,070.00
  OriGene Technologies GmbH

CD208 / LAMP3 (28-381, His-tag)
CD208 / LAMP3 Human Purified > 90 % by SDS – PAGE Insect cells
50 µg / €320.00
  OriGene Technologies GmbH

CD208 / LAMP3
CD208 / LAMP3 Human Human HEK293T cells
  Abnova Taiwan Corp.

CD208 / LAMP3
CD208 / LAMP3 Human
  Abnova Taiwan Corp.

Positive controls for CD208 / LAMP3 (2 products)

Catalog No. Species Pres. Purity   Source  

LAMP3 Lysate
Western Blot: LAMP3 Lysate [NBL1-12432] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for LAMP3
  Novus Biologicals Inc.

LAMP3 overexpression lysate
LAMP3 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

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