Product Description for CD209 / DC-SIGN
Mouse anti Human, Sheep CD209 / DC-SIGN 128G8.43.
Properties: (Extracell. Dom.)
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot, Flow Cytometry.
Properties: (Extracell. Dom.)
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot, Flow Cytometry.
Properties for CD209 / DC-SIGN
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 50 µg |
| Synonyms | C-type lectin domain family 4 member L, CLEC4L, DC-SIGN1, DCSIGN, DCSIGN1, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1 |
| Presentation | Purified |
| Reactivity | Hu, Sh |
| Applications | C, F, WB |
| Clonality | Monoclonal |
| Clone | 128G8.43 |
| Host | Mouse |
| Isotype | IgG1 |
| Shipping to | Germany, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Dendritics SAS |
Datasheet Extract
| Immunogen |
|
|---|---|
| Property | Extracell. Dom. |
| Isotype control | AM03095PU-N, SM10P (for use in human samples) |
| Application | Antigen uptake, FACS surface, ImmunoHistoChemistry frozen sections, Western Blot. |
| Background | We have generated an antibody recognizing an antigen which has a tissular distribution and a size (western blot) identical to DC-SIGN. This antibody does not recognize DC-SIGN 1 expressed in HeLa cells. DCSIGN (“DC Specific, ICAM-3 Grabbing, Nonintegrin”) / CD209 is a type II membrane protein with an external mannose-binding C-type lectin domain, DC-SIGN is expressed by immature and mature dendritic cells (DC). In the skin, DC-SIGN+ DC are exclusively located in the dermis. DC-SIGN binds to ICAM-3 on resting T cells, establishing DC-T cell contact and adaptive immunity. DC-SIGN is a high affinity receptor for HIV gp120, allowing HIV capture and transmission to CD4+ T cells. In addition to HIV, DC-SIGN is a receptor for a number of other viral and cellular pathogens including Mycobacterium Tuberculosis, and is a major player in microbial evasion of the immune system. (Geijtenbeek, T and al, Cell; 2000; 100: 587-597; van Kooyk Y and al, Nat. Rev. Immunol.; 2003; 3: 697- 709) |
| Concentration | 0.5 mg/ml |
| Product Citations |
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| Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
| Format |
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| Specificity |
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| Gene ID | 30835 |
Accessory Products
Proteins and/or Positive Controls
Proteins for CD209 / DC-SIGN (6 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00030835-G01 |
CD209 / DC-SIGN |
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|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
| H00030835-P01-10 |
CD209 / DC-SIGN |
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|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00030835-P01-25 |
CD209 / DC-SIGN |
||||||
|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00030835-Q01-10 |
CD209 / DC-SIGN |
||||||
|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00030835-Q01-25 |
CD209 / DC-SIGN |
||||||
|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| NBP1-46043 |
CD209 / DC-SIGN |
||||||
![Densitometry: DC-SIGN Protein [NBP1-46043] - Post-translational modifications result in protein heterogeneity. The densitometry scan, derived from the 2D gel image above, demonstrates the purified human cell expressed protein exists in multiple glycoforms, which differ according to their level of post-translational modification. Expression of these glycoforms is highly significant for cell biology, as they more closely resemble the native human proteins. The triangle indicates theoretical pI and MW.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/DC-SIGN%20Protein-Densitometry-NBP1-46043-img0003.jpg)
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
Positive controls for CD209 / DC-SIGN (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00030835-T01 |
CD209 293T Cell Transient Overexpression Lysate(Denatured) |
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|
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| Abnova Taiwan Corp. | |||||||
| NBL1-08921 |
CD209 / DC-SIGN Lysate |
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![Western Blot: DC-SIGN Lysate [NBL1-08921] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for CD209](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/DC-SIGN%20Lysate-Western%20Blot-NBL1-08921-img0001.jpg) |
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| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for CD209 / DC-SIGN (11 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1253AP |
Mouse IgG (H+L chain) antibody |
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|
|
Rabbit | AP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253B |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253F |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | E, ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1253HRP |
Mouse IgG (H+L chain) antibody |
||||||
|
Rabbit | HRP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253TR |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Texas Red | ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1403R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Rabbit | PE | F | ||||
| OriGene Technologies GmbH | |||||||
| R1405R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1455R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1457C2 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C3 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C5 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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