Product Description for MIP3 alpha / CCL20
Mouse anti Human, Macaque MIP3 alpha / CCL20 319F6.07.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, ELISA (capture), Functional assay.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, ELISA (capture), Functional assay.
Properties for MIP3 alpha / CCL20
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 50 µg |
| Synonyms | Beta chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CCL20, DC marker, Dendritic Cell Marker, Exodus-1, LARC, Liver and activation-regulated chemokine, MIP-3 alpha, MIP3A, Macrophage inflammatory protein 3 alpha, SCYA20, Small-inducible cytokine A20 |
| Presentation | Purified |
| Reactivity | Hu, Macaque |
| Applications | C, E, E(capture), FN |
| Clonality | Monoclonal |
| Clone | 319F6.07 |
| Host | Mouse |
| Isotype | IgG2b |
| Shipping to | Germany, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Dendritics SAS |
Datasheet Extract
| Immunogen |
|
|---|---|
| Isotype control | AM03110PU-N, SM12P |
| Application | DDX0430P-50 / DDX0430P-100 Purified: Blocking migration, ELISA capture, IHC |
| Background | Macrophage inflammatory protein (MIP)-3α/ CCL20 is a CC-type chemokine mapped to chromosome 2 in humans. Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium. MIP-3α plays a central role in LC precursor recruitment into the epithelium during inflammation. (a) Among DC populations, MIP-3α is the most potent chemokine inducing the selective migration of in vitro-generated CD34+ hematopoietic progenitor cell-derived LC precursors and skin LCs in accordance with the restricted MIP-3α receptor (CC chemokine receptor 6) expression by these cells. (b) MIP-3α is mainly produced by epithelial cells, and the migration of LC precursors induced by the supernatant of activated skin keratinocytes is blocked with an antibody against MIP-3α. (c) In vivo, MIP-3α is selectively produced at sites of inflammation as illustrated in tonsils and lesional psoriatic skin where MIP-3α upregulation appears associated with an increase in LC turnover. (d) The secretion of MIP-3α is strongly upregulated by cells of epithelial origin after inflammatory stimuli (interleukin 1β plus TNFα) or T cell signals. (Dieu-Nosjean et al, J;Exp.med, 2000 192: 705-18). |
| Concentration | 0.5 mg/ml |
| Product Citations |
|
| Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
| Format |
|
| Specificity |
|
| Gene ID | 6364 |
Accessory Products
Proteins and/or Positive Controls
Proteins for MIP3 alpha / CCL20 (16 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP723313 |
MIP3 alpha / CCL20 (transcript variant 1) |
||||||
|
Human |
> 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
20 µg /
€230.00
|
|||
| OriGene Technologies, Inc. | |||||||
| TP723810 |
MIP3 alpha / CCL20 (transcript variant 1) |
||||||
|
Human |
> 98 % Preparation: . Purity Detail: >98%, as determined by Coomassie stained SDS-PAGE. |
E. coli |
10 µg /
€195.00
|
|||
| OriGene Technologies, Inc. | |||||||
| AR09857PU-L |
MIP3 alpha / CCL20 (27-96, His-tag) |
||||||
|
Human | Purified | > 85 % | E. coli |
0.25 mg /
€1,070.00
|
||
| OriGene Technologies GmbH | |||||||
| AR09857PU-N |
MIP3 alpha / CCL20 (27-96, His-tag) |
||||||
|
|
Human | Purified | > 85 % | E. coli |
50 µg /
€400.00
|
||
| OriGene Technologies GmbH | |||||||
| PA109 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | > 99 % | E. coli | ||||
| OriGene Technologies GmbH | |||||||
| PA109X |
MIP3 alpha / CCL20 |
||||||
|
|
Human | > 99 % | E. coli | ||||
| OriGene Technologies GmbH | |||||||
| PA254 |
MIP3 alpha / CCL20 |
||||||
|
|
Mouse | > 99 % | E. coli | ||||
| OriGene Technologies GmbH | |||||||
| PA254X |
MIP3 alpha / CCL20 |
||||||
|
|
Mouse | > 99 % | E. coli | ||||
| OriGene Technologies GmbH | |||||||
| H00006364-P01 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
| P3654 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
| NBP1-43160-5 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
| NBP1-43160-25 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
| NBP1-43161-5 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
| NBP1-43161-25 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
| NBP1-50994-0.25 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
| NBP1-50994-50 |
MIP3 alpha / CCL20 |
||||||
|
|
Human | Purified | |||||
| Novus Biologicals Inc. | |||||||
Positive controls for MIP3 alpha / CCL20 (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| LY401468 |
CCL20 overexpression lysate |
||||||
|
0.1 mg /
€295.00
|
||||||
| OriGene Technologies, Inc. | |||||||
| NBL1-08850 |
Macrophage Inflammatory Protein 3 alpha Lysate |
||||||
![Western Blot: Macrophage Inflammatory Protein 3 alpha Lysate [NBL1-08850] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for CCL20](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Macrophage%20Inflammatory%20Protein%203%20alpha%20Lysate-Western%20Blot-NBL1-08850-img0001.jpg) |
|||||||
| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for MIP3 alpha / CCL20 (11 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1253AP |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | AP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253B |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253F |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | E, ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1253HRP |
Mouse IgG (H+L chain) antibody |
||||||
|
Rabbit | HRP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253TR |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Texas Red | ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1403R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Rabbit | PE | F | ||||
| OriGene Technologies GmbH | |||||||
| R1405R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1455R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1457C2 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C3 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C5 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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