Product Description for CD283 / TLR3
Mouse anti Canine, Human, Mouse, Porcine, Rat, Sheep CD283 / TLR3 722E2.01.
Presentation: Alexa Fluor 647
Product is tested for Flow Cytometry.
Presentation: Alexa Fluor 647
Product is tested for Flow Cytometry.
Properties for CD283 / TLR3
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 50 µg |
| Synonyms | Toll-like receptor 3 |
| Presentation | Alexa Fluor 647 |
| Reactivity | Can, Hu, Ms, Por, Rt, Sh |
| Applications | F |
| Clonality | Monoclonal |
| Clone | 722E2.01 |
| Host | Mouse |
| Isotype | IgM |
| Shipping to | Germany, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Dendritics SAS |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | DDX0472P-50 / DDX0472P-100 Purified: FACS intracellular, ImmunoHistoChemistry frozen sections, Western Blot. DDX0472A488-50 / DDX0472A488-100 Alexa-fluor®488: FACS intracellular, ImmunoFluorescence. DDX0472A546-50 / DDX0472A546-100 Alexa-fluor®546: ImmunoFluorescence. DDX0472A647-50 / DDX0472A647-100 Alexa- fluor®647: FACS intracellular. DDX0472B-50 / DDX0472B-100 Biotin: ImmunoHistoChemistry frozen sections, Western Blot. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before using. |
| Background | The Toll-like receptor (TLR) family has recently emerged as key for sensing microbial infections and triggering inflammatory and innate responses. Ten TLRs have been cloned in humans. They share structural and functional homologies, as they are all able to detect micro-organisms through direct recognition of conserved Pathogen Associated Molecular Patterns (PAMPs) such as bacterial LPS or viral dsRNA. Ligand recognition is mediated through the C-terminal Leucine Rich Repeat region, while signalling involves the N-terminal Toll/Interleukin-1 Receptor (TIR) domain. TLR3 has been identified as a receptor for dsRNA. Unlike other TLRs, the cytoplasmic tail of TLR3 does not contain a conserved proline residue, whose mutation confers LPS unresponsiveness in C3H/HeJ mice. TLR3 is the only TLR that signals exclusively through the TIR-containing adaptor TRIF (TIR-containing adaptor inducing IFNβ), which activates the transcription factors IRF3 and NFκB, and triggers type I interferon secretion. TLR3 is expressed in various cell types, such as fibroblasts, dendritic cells (DCs), or NK cells. While TLR3 is expressed at the cell surface in fibroblasts, it is mostly found in intracytoplasmic vesicles in DCs. (Akira S et al, 2004, Nat Rev Immunol,4:499-511; Bonnefond-Rebeix C. et al.,2007, Veterinary Immunol and Immunopath, 118, 134). |
| Concentration | 0.5 mg/ml |
| Product Citations |
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| General Readings | |
| Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
| Format |
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| Specificity |
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| Gene ID | 7098 |
Accessory Products
Proteins and/or Positive Controls
Proteins for CD283 / TLR3 (6 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP723450 |
CD283 / TLR3 |
||||||
|
Human |
> 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
25 µg /
€230.00
|
|||
| OriGene Technologies, Inc. | |||||||
| AR31102PU-N |
CD283 / TLR3 |
||||||
|
|
Human | Purified | > 95 % pure by SDS-PAGE and HPLC analyses | HEK293 cells | |||
| OriGene Technologies GmbH | |||||||
| AR31102PU-S |
CD283 / TLR3 |
||||||
|
|
Human | Purified | > 95 % pure by SDS-PAGE and HPLC analyses | HEK293 cells | |||
| OriGene Technologies GmbH | |||||||
| H00007098-G01 |
CD283 / TLR3 |
||||||
|
|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
| H00007098-Q01-10 |
CD283 / TLR3 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00007098-Q01-25 |
CD283 / TLR3 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
Positive controls for CD283 / TLR3 (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| LY418801 |
TLR3 overexpression lysate |
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|
|||||||
| OriGene Technologies, Inc. | |||||||
Recommended Secondary Antibodies for CD283 / TLR3 (10 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1349AP |
Mouse IgA (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| OriGene Technologies GmbH | |||||||
| R1349B |
Mouse IgA (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| OriGene Technologies GmbH | |||||||
| R1349F |
Mouse IgA (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| OriGene Technologies GmbH | |||||||
| R1349HRP |
Mouse IgA (+IgG +IgM) antibody |
||||||
|
|
Goat | HRP | |||||
| OriGene Technologies GmbH | |||||||
| R1349T |
Mouse IgA (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| OriGene Technologies GmbH | |||||||
| R1349TR |
Mouse IgA (H+L chain) antibody |
||||||
|
|
Goat | Texas Red | |||||
| OriGene Technologies GmbH | |||||||
| SP1018AP |
Mouse IgM (Mu chain specific), adsorbed antibody |
||||||
|
|
Goat | AP | Ms | ||||
| OriGene Technologies GmbH | |||||||
| SP1018F |
Mouse IgM (Mu chain specific), adsorbed antibody |
||||||
|
|
Goat | FITC | Ms | ||||
| OriGene Technologies GmbH | |||||||
| SP1018HRP |
Mouse IgM (Mu chain specific), adsorbed antibody |
||||||
|
|
Goat | HRP | Ms | C, E, P | |||
| OriGene Technologies GmbH | |||||||
| SP1018R |
Mouse IgM (Mu chain specific), adsorbed antibody |
||||||
|
|
Goat | PE | Ms | ||||
| OriGene Technologies GmbH | |||||||
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