Product Description for 17-beta HSD8 / HSD17B8
17-beta HSD8 / HSD17B8.
Presentation: Purified
Presentation: Purified
Properties for 17-beta HSD8 / HSD17B8
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | 17-beta-hydroxysteroid dehydrogenase 8, 3-oxoacyl-[acyl-carrier-protein] reductase, Estradiol 17-beta-dehydrogenase 8, FABGL, HKE6, Protein Ke6, RING2, Really interesting new gene 2 protein, Testosterone 17-beta-dehydrogenase 8 |
| Presentation | Purified |
| Molecular weight | 29.1 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 95 % |
| Background | HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Rotinen M., et al. (2009) Endocrinol 200:85-92. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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