AM10099SU-N SMARCB1 antibody

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1 ml / €670.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human SMARCB1 25

Product Description for SMARCB1

Mouse anti Human SMARCB1 25.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for SMARCB1

Product Category Primary Antibodies
Quantity 1 ml
Synonyms BAF47, BRG1-associated factor 47, INI1, Integrase interactor 1 protein, SNF5 homolog, SNF5L1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone 25
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q12824
Immunogen:
Mouse BAF47 amino acids 257-359
GeneID:
6598
Application Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100
Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
Use Polymer anti Mouse/Rabbit IgG as a detection system.
Positive Control: Brain or astrocytoma.
Background The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable.
Concentration 0.075 mg/ml
Storage Store the antibody undiluted at 2-8°C. 
Shelf life: one year from despatch.
Format
State:
Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Supernatant
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1 antibody. MRTs also originate from the kidney and soft tissues.
Cellular Localization: Nuclear.
Gene ID 3623

Accessory Products

Proteins and/or Positive Controls

Proteins for SMARCB1 (5 products)

Catalog No. Species Pres. Purity   Source  

SMARCB1 (transcript variant 2)

SMARCB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

SMARCB1

SMARCB1 Human Purified
  Abnova Taiwan Corp.

SMARCB1

SMARCB1 Human Purified
  Abnova Taiwan Corp.

SMARCB1

SMARCB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

SMARCB1

SMARCB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for SMARCB1 (2 products)

Catalog No. Species Pres. Purity   Source  

SMARCB1 293T Cell Transient Overexpression Lysate(Denatured)

SMARCB1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

SMARCB1 overexpression lysate

SMARCB1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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