Product Description for PDGFA
PDGFA.
Presentation: Purified
Presentation: Purified
Properties for PDGFA
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 2 µg |
| Synonyms | PDGF A, PDGF alpha, PDGF subunit A, PDGF-1, PDGF-A, PDGF1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha, Platelet-derived growth factor subunit A |
| Presentation | Purified |
| Molecular weight | 28.5 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % pure by SDS-PAGE and visualised by silver stain. |
| Add. information | Always centrifuge product before opening vial! |
| Background | PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFRalpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. |
| Storage | Store lyophilized human PDGF-AA at -20°C. Reconstituted PDGF-AA should be stored in working aliquots at -20°C to -70°C. Avoid repeated freeze-thaw cycles! Shelf life: One year from despatch. |
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