Product Description for Interleukin-1 beta / IL-1B
Interleukin-1 beta / IL-1B.
Presentation: Purified
Presentation: Purified
Properties for Interleukin-1 beta / IL-1B
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 2 µg |
| Synonyms | Catabolin, IL-1 beta, IL1 beta, IL1B, IL1F2 |
| Presentation | Purified |
| Molecular weight | 17 kDa |
| Source | E. coli |
| Specactivity | 2 x |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 98 % pure by SDS-PAGE and Silver stain |
| Add. information | Range: 0.1-10.0 ng/ml |
| Background | Interleukin-1 beta (IL-1beta) is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL1F1) and IL1 beta (IL1F2), which are the products of distinct genes. IL- 1alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta converting enzyme (Caspase1/ICE) to generate the active cytokine. The mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67% 78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta. |
| General Readings |
|
| Storage | Store lyophilized at RT for 3 weeks or (preferably in a desiccator) at -20°C for longer. Following reconstitution store the antibody undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Description |
|
| Format |
|
Compare Products
You have no items to compare.
My Cart
You have no items in your shopping cart.
