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BP1006 Candida albicans antibody

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1 ml / €480.00
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Quick Overview

Rabbit anti Candida Candida albicans

BP1006

Product Description for Candida albicans

Rabbit anti Candida Candida albicans.
Presentation: Purified
Product is tested for Paraffin Sections, Immunoelectrophoresis, Immunodiffusion, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence.

Properties for Candida albicans

Product Category Primary Antibodies
Quantity 1 ml
Synonyms C. albicans
Presentation Purified
Reactivity Candida
Applications E, ICC/IF, ID, Ie, P
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Candida albicans, type A (ATTCC #32354).
Application ELISA. 
Immunofluorescence. 
Immunohistochemistry. 
Double Diffusion.
CIE (Counter Immunoelectrophoresis).
Also suitable for Conjugation purposes.
Use neat in gel-precipitin reactions.
Background Candida albicans is the most frequently isolated fungal pathogen of Humans, affecting immunocompromised patients ranging from premature infants to AIDS sufferers. Systemic infections have an attributed mortality of 30-50%. C. albicans is a diploid organism which has eight sets of homologous chromosomes. It has a genome of approximately 16 Mb (haploid), about 30% greater than S. cerevisiae (baker's yeast).
Concentration 4-5 mg/ml (OD280 nm, E0.1% = 1.4)
Product Citations
Purchased from Acris:
1. Schild L, Heyken A, de Groot PW, Hiller E, Mock M, de Koster C, et al. Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell. 2011 Jan;10(1):98-109. doi: 10.1128/EC.00210-10. Epub 2010 Nov 19. PubMed PMID: 21097664.
2. Goyer M, Loiselet A, Bon F, L'Ollivier C, Laue M, Holland G, et al. Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier. PLoS One. 2016 Mar 2;11(3):e0149159. doi: 10.1371/journal.pone.0149159. eCollection 2016. PubMed PMID: 26933885. 
3. Klaile, E;Müller, MM;Schäfer, MR;Clauder, AK;Feer, S;Heyl, KA;Stock, M;Klassert, TE;Zipfel, PF;Singer, BB;Slevogt, H. Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells MBio 2017.  8, 2. PubMed PMID: 28292985. 
4. Allert, S;Förster, TM;Svensson, CM;Richardson, JP;Pawlik, T;Hebecker, B;Rudolphi, S;Juraschitz, M;Schaller, M;Blagojevic, M;Morschhäuser, J;Figge, MT;Jacobsen, ID;Naglik, JR;Kasper, L;Mogavero, S;Hube, B. Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers. MBio 2018, 9, 3. PubMed PMID: 29871918
General Readings
  1. Brand A, Vacharaksa A, Bendel C, Norton J, Haynes P, Henry-Stanley M, et al. An internal polarity landmark is important for externally induced hyphal behaviors in Candida albicans. Eukaryot Cell. 2008 Apr;7(4):712-20. doi: 10.1128/EC.00453-07. Epub 2008 Feb 15. PubMed PMID: 18281602. (Free PMC Article available, 6 images available)
  2. Fratti RA, Belanger PH, Ghannoum MA, Edwards JE, Filler SG. Endothelial cell injury caused by Candida albicans is dependent on iron. Infect Immun. 1998 Jan;66(1):191-6. PubMed PMID: 9423857. (Free PMC Article available, 4 images available)
  3. Tsuchimori N, Sharkey LL, Fonzi WA, French SW, Edwards JE, Filler SG. Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells. Infect Immun. 2000 Apr;68(4):1997-2002. PubMed PMID: 10722594. (Free PMC Article available, 3 images available)
  4. Phan QT, Fratti RA, Prasadarao NV, Edwards JE, Filler SG. N-cadherin mediates endocytosis of Candida albicans by endothelial cells. J Biol Chem. 2005 Mar 18;280(11):10455-61. Epub 2005 Jan 4. PubMed PMID: 15632157.
  5. Phan QT, Belanger PH, Filler SG. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infect Immun. 2000 Jun;68(6):3485-90. PubMed PMID: 10816502. (Free PMC Article available, 5 images available)
  6. Martinez-Lopez R, Park H, Myers CL, Gil C, Filler SG. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells. Eukaryot Cell. 2006 Jan;5(1):140-7. PubMed PMID: 16400176. (Free PMC Article available, 5 images available)
  7. Palmer GE, Kelly MN, Sturtevant JE. The Candida albicans vacuole is required for differentiation and efficient macrophage killing. Eukaryot Cell. 2005 Oct;4(10):1677-86. PubMed PMID: 16215175. (Free PMC Article available, 6 images available)
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A Chromatography
Buffer System:
0.01M PBS, pH 7.2 containing 0.09% Sodium Azide as preservative without stabilizing proteins
State:
Liquid purified Ig fraction (>95% pure)
Purified
Specificity
Specificity:
Recognizes numerous proteins in a soluble C. albicans extract (IEP).
Has not been absorbed and does cross-react with other Yeasts.
Negative against Human serum, urine and spinal fluid.

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