Product Description for PSMB10
PSMB10.
Presentation: Purified
Presentation: Purified
Properties for PSMB10
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 10 µg |
| Synonyms | EC=3.4.25.1, MECL1, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1, PSMB10, Proteasome MECl-1, Proteasome subunit beta type-10, Proteasome subunit beta-2i |
| Presentation | Purified |
| Molecular weight | 26.9 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 90 % |
| Background | PSMB10 is a member of the proteasome B-type family, also known as the T1B family, which is a 20S core beta subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. Expression of the PSMB10 gene is induced by gamma interferon, and PSMB10 replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| General Readings | Foss G.S., et al. (1998) Biochim. Biophys. Acta. 1402:17-28. Hisamatsu H., et al. (1996) J. Exp. Med. 183:1807-1816. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. |
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