Product Description for CHAT
CHAT.
Properties for CHAT
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 10 µg |
| Synonyms | CHOACTase, ChAT, Choline O-acetyltransferase, Choline acetylase, EC=2.3.1.6 |
| Reactivity | Rt |
| Source | E. coli |
| Species (Protein) | Rat |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | Immunohistochemistry on Frozen Sections: For use in blocking the staining of antibodies to Choline Acetyltransferase (BP348). Suggested concentrations 2-5 µg/ml; The antigen should be incubated with the antibody for 3 hours at 4°C before being used on tissue sections. |
| Background | Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer's disease, Down and Rett syndromes. Choline acetyltransferase recruits choline for the synthesis of acetylcholine at preganglionic parasympathetic and sympathetic fibres. It is also present at parasympathetic postganglionic fibres. |
| Concentration | 0.25 mg/ml |
| Storage | The protein can be shipped at 2-8°C. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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